Antifungal activity of 2-chloro-N-phenylacetamide, docking and molecular dynamics studies against clinical isolates of Candida tropicalis and Candida parapsilosis.
Shellygton Lima SilvaFillipe de Oliveira PereiraLaisa Vilar CordeiroHermes Diniz NetoMayara Dos Santos MaiaHelivaldo Diogenes da Silva SouzaPetrônio F de Athayde-FilhoMarcus Tullius ScottiLuciana ScottiEdeltrudes de Oliveira LimaPublished in: Journal of applied microbiology (2022)
Our study provides the first evidence that A1Cl, a novel synthetic drug, has fungicidal effects against C. tropicalis and C. parapsilosis. Furthermore, in vitro and ex vivo biofilms assays have demonstrated the potential antibiofilm of A1Cl. The mechanism of action involves inhibiting the enzyme DHFR, which was supported by in silico analyses. Therefore, this potential can be explored as a therapeutic alternative for onychomycosis and, at the same time, contribute to decreasing the resistance of clinical isolates of C. tropicalis and C. parapsilosis.