N-Heterocyclic carbene (NHC)-catalysed atom economical construction of 2,3-disubstituted indoles.

Battu HarishManyam SubbireddySurisetti Suresh

Published in: Chemical communications (Cambridge, England) (2018)

A novel organocatalytic approach, harnessing the unique reactivities of N-heterocyclic carbenes (NHCs), has been revealed for the construction of indoles. The NHC-catalysed atom economical synthesis of a wide range of 2-substituted indole-3-acetic acid derivatives is displayed. Strategic application of the developed method was demonstrated for a short synthesis of a cyclin-dependent kinase (CDK) inhibitor: paullone.

Keyphrases

cell cycle
molecular dynamics
molecular docking
big data
tyrosine kinase
machine learning
transition metal