Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents.
Reyaz Hassan MirGoutami GodavariNasir Ali SiddiquiBilal AhmadRamzi A A MothanaRiaz UllahOmer M AlmarfadiSanjay M JachakMubashir Hussain MasoodiPublished in: Drug design, development and therapy (2021)
Herein, we report a series of 15 new arylidene derivatives of oleanolic acid by Claisen Schmidt condensation reaction. All the compounds synthesized were screened for their anti-inflammatory activity against NO, TNF-α and IL-6. From the data, it was evident that most of the compounds exhibited better anti-inflammatory activity.