Mechanisms of medicinal, pharmaceutical, and immunomodulatory action of probiotics bacteria and their secondary metabolites against disease management: an overview.
Sundas NasreenShaukat AliSaiqa AndleebMuhammad SummerTauqeer HussainKaleem ImdadChaman AraHafiz Muhammad TahirPublished in: Folia microbiologica (2024)
Probiotics or bacteriotherapy is today's hot issue for public entities (Food and Agriculture Organization, and World Health Organization) as well as health and food industries since Metchnikoff and his colleagues hypothesized the correlation between probiotic consumption and human's health. They contribute to the newest and highly efficient arena of promising biotherapeutics. These are usually attractive in biomedical applications such as gut-related diseases like irritable bowel disease, diarrhea, gastrointestinal disorders, fungal infections, various allergies, parasitic and bacterial infections, viral diseases, and intestinal inflammation, and are also worth immunomodulation. The useful impact of probiotics is not limited to gut-related diseases alone. Still, these have proven benefits in various acute and chronic infectious diseases, like cancer, human immunodeficiency virus (HIV) diseases, and high serum cholesterol. Recently, different researchers have paid special attention to investigating biomedical applications of probiotics, but consolidated data regarding bacteriotherapy with a detailed mechanistically applied approach is scarce and controversial. The present article reviews the bio-interface of probiotic strains, mainly (i) why the demand for probiotics?, (ii) the current status of probiotics, (iii) an alternative to antibiotics, (iv) the potential applications towards disease management, (v) probiotics and industrialization, and (vi) futuristic approach.
Keyphrases
- human immunodeficiency virus
- highly efficient
- antiretroviral therapy
- healthcare
- hepatitis c virus
- hiv infected
- public health
- hiv positive
- infectious diseases
- human health
- mental health
- current status
- endothelial cells
- emergency department
- liver failure
- sars cov
- escherichia coli
- climate change
- machine learning
- squamous cell carcinoma
- risk assessment
- health information
- ms ms
- intensive care unit
- papillary thyroid
- systematic review
- social media
- men who have sex with men
- low density lipoprotein
- clostridium difficile