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A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer.

Robert J HuangIgnacio A WichmannAndrew SuAnuja SatheMiranda V ShumSusan M GrimesRithika MekaAlison AlmedaXiangqi BaiJeanne ShenQuan NguyenManuel R AmievaJoo Ha HwangHanlee P Ji
Published in: bioRxiv : the preprint server for biology (2023)
using an integrated multi-omics approach, we identified a novel 26-gene expression signature for high-OLGIM precursors at increased risk for GC. We found this signature localizes to aberrant intestinal stem-like cells within the metaplastic microenvironment. These findings hold important translational significance for future prevention and early detection efforts.
Keyphrases
  • gene expression
  • dna methylation
  • stem cells
  • genome wide
  • current status
  • single cell
  • quality improvement
  • mass spectrometry
  • gas chromatography