A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer.
Robert J HuangIgnacio A WichmannAndrew SuAnuja SatheMiranda V ShumSusan M GrimesRithika MekaAlison AlmedaXiangqi BaiJeanne ShenQuan NguyenManuel R AmievaJoo Ha HwangHanlee P JiPublished in: bioRxiv : the preprint server for biology (2023)
using an integrated multi-omics approach, we identified a novel 26-gene expression signature for high-OLGIM precursors at increased risk for GC. We found this signature localizes to aberrant intestinal stem-like cells within the metaplastic microenvironment. These findings hold important translational significance for future prevention and early detection efforts.