Peptide Tyrosine-Tyrosine Triggers GLP-2-Mediated Intestinal Hypertrophy After Roux-en-Y Gastric Bypass.

Gonzalo-Martín Pérez-AranaAlfredo Díaz-GómezAlonso Camacho-RamírezAntonio Ribelles-GarcíaDavid Almorza-GomarManuel Gracia-RomeroJose Arturo Prada-Oliveira

Published in: Obesity surgery (2022)

The postprandial ileal PYY secretion is enhanced after RYGB. This increase mediates GLP-2 release through its binding to the Y2 receptor on L-cells. This mechanism plays a role in alimentary limb hypertrophy after surgery.

Keyphrases

roux en y gastric bypass
weight loss
gastric bypass
obese patients
induced apoptosis
cell cycle arrest
bariatric surgery
endoplasmic reticulum stress
blood glucose
type diabetes
cell death
oxidative stress
binding protein