Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone.

Sang-Hyun Kim Jun-Hyeok Moon Seong-Un Jeong Ho-Hyun Jung Chan-Su Park Bang Yeon Hwang Chong-Kil Lee

Published in: International journal of nanomedicine (2019)

The present study demonstrates that oral feeding as well as intravenous injection of poly(lactic-co-glycolic acid) NPs encapsulating both antigen and Dex is a useful means of inducing antigen-specific immune tolerance, which is crucial for the treatment of autoimmune diseases.

Keyphrases

high dose
drug delivery
low dose
replacement therapy
walled carbon nanotubes