Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults.

Anouschka C PronkL J SeppalaK TrajanoskaN StringaB van de LooL C P G M de GrootN M van SchoorFotios Koskeridis Georgios MarkozannesE NtzaniA G UitterlindenF RivadeneiraB H StrickerN van der Velde

Published in: PloS one (2022)

This is the first study showing that certain genetic variants modify antidepressant-related fall risk. The results were not always consistent across the studies and should be validated in a study with a prospective design. However, pharmacogenetics might have value in antidepressant (de)prescribing in falls prevention.

Keyphrases

major depressive disorder
primary care
physical activity
bipolar disorder
emergency department
adverse drug
electronic health record