Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival.

Linda KachuriGeno A GuerraGeorge A WendtHelen M HansenAnnette M MolinaroPaige BracciLucie McCoyTerri RiceJohn K WienckeJeanette E Eckel-PassowRobert B JenkinsMargaret WrenschStephen S Francis

Published in: medRxiv : the preprint server for health sciences (2023)

This study suggests that genetic determinants of peripheral blood cell counts influence subtype-specific glioma susceptibility and mortality, with potential effects on the tumor immune microenvironment. These findings may have disease management implications.

Keyphrases

peripheral blood
single cell
cell therapy
genome wide
stem cells
copy number
cardiovascular events
cardiovascular disease
risk factors
gene expression
risk assessment
climate change