Dendritic cells mediated by small extracellular vesicles derived from MSCs attenuated the ILC2 activity via PGE2 in patients with allergic rhinitis.

Xiao-Qing LiuYa-Qi PengLong-Xin HuangChan-Gu LiPeng-Peng KuangDe-Hua ChenZi-Cong WuBi-Xin HeZhi-Rou ZhouQing-Ling Fu

Published in: Stem cell research & therapy (2023)

We demonstrated that MSC-sEVs were able to dampen the activating effects of mDCs on ILC2s in patients with AR. Mechanismly, the PGE2-EP2/4 axis played an essential role in the immunomodulatory effects of sEV-mDCs on ILC2s. Herein, we provided new insights into the mechanism underlying the therapeutic effects of MSC-sEVs in allergic airway inflammation.

Keyphrases

allergic rhinitis
dendritic cells
nk cells
immune response
signaling pathway
regulatory t cells