Antimicrobial use among adult inpatients at hospital sites within the Canadian Nosocomial Infection Surveillance Program: 2009 to 2016.
Wallis RudnickMichelle ScienceDaniel J G ThirionKahina AbdesselamKelly B ChoiLinda PeludeKanchana AmaratungaJeannette L ComeauBruce DaltonJohan DelportRita DhamiJoanne EmbreeYannick ÉmondGerald EvansCharles FrenetteSusan FrytersGreg GermanJennifer M GrantJennifer HappeKevin KatzPamela KibseyJustin KosarJoanne M LangleyBonita E LeeMarie-Astrid LefebvreJerome A LeisAllison McGeerHeather L NevilleAndrew SimorKathryn SlayterKathryn N SuhAlena Tse-ChangKarl WeissJohn M Conlynull nullPublished in: Antimicrobial resistance and infection control (2020)
This study represents the largest collection of dispensed antimicrobial use data among inpatients in Canada to date. Between 2009 and 2016, there was a significant 12% decrease in AMU, driven primarily by a 47% decrease in fluoroquinolone use. Modest absolute increases in parenteral ceftriaxone and oral amoxicillin-clavulanate use were noted but contributed a small amount of total AMU. Ongoing national surveillance is crucial for establishing benchmarks and antimicrobial stewardship guidelines.