Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease.
Helena Cortez-PintoRodrigo LiberalSusana LopesMariana Verdelho MachadoJoana CarvalhoTeresa DiasArsénio SantosCláudia AgostinhoPedro FigueiredoRafaela LoureiroAlexandra MartinsGonçalo AlexandrinoIsabel CotrimCarina LealJosé PresaMónica MesquitaJoana NunesCatarina GouveiaAna Horta E ValeAna Luísa AlvesMariana CoelhoLuís MaiaIsabel PedrotoAntónio BanhudoJoão Sebastião PintoMarta Vargas GomesJoana OliveiraValeska AndreozziFilipe CalinasPublished in: United European gastroenterology journal (2021)
A considerable proportion of patients showed incomplete biochemical response to UDCA treatment according to Paris II criteria. Cirrhosis, elevated GGT and ALP at diagnosis were identified as associated risk factors for incomplete response. Early identification of patients at risk of incomplete response could improve treatment care and guide clinical decision to a more careful patient monitorization.