Putative roles for homeostatic plasticity in epileptogenesis.
Naoum P IssaKatherine C NunnShasha WuHiba A HaiderJames X TaoPublished in: Epilepsia (2023)
Homeostatic plasticity allows neural circuits to maintain an average activity level while preserving the ability to learn new associations and efficiently transmit information. This dynamic process usually protects the brain from excessive activity, like seizures. However, in certain contexts, homeostatic plasticity might produce seizures, either in response to an acute provocation or more chronically as a driver of epileptogenesis. Here, we review three seizure conditions in which homeostatic plasticity likely plays an important role: acute drug withdrawal seizures, posttraumatic or disconnection epilepsy, and cyclic seizures. Identifying the homeostatic mechanisms active at different stages of development and in different circuits could allow better targeting of therapies, including determining when neuromodulation might be most effective, proposing ways to prevent epileptogenesis, and determining how to disrupt the cycle of recurring seizure clusters.
Keyphrases
- temporal lobe epilepsy
- liver failure
- drug induced
- respiratory failure
- aortic dissection
- white matter
- emergency department
- hepatitis b virus
- health information
- multiple sclerosis
- drug delivery
- body mass index
- resting state
- weight gain
- physical activity
- extracorporeal membrane oxygenation
- brain injury
- acute respiratory distress syndrome
- blood brain barrier
- mechanical ventilation
- electronic health record