Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
Małgorzata Krzystek-KorpackaJerzy WiśniewskiMariusz G FleszarIwona Bednarz-MisaAgnieszka Bronowicka-SzydełkoMałgorzata GackaLeszek MasłowskiKrzysztof KędziorWojciech WitkiewiczAndrzej GamianPublished in: Oxidative medicine and cellular longevity (2019)
Chronic wounds in the course of cardiometabolic diseases are associated with reduced NO and arginine availability due to ADMA and SDMA accumulation rather than arginine deficiency, not supporting its supplementation. Wound character seems to affect NO bioavailability and wound etiology-arginine bioavailability. Arginine concentration and its availability are more markedly reduced at the local level than the systemic level.