Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease.

Kento Takenaka Ami Kawamoto Shuji Hibiya Kohei Suzuki Toshimitsu Fujii Maiko Motobayashi Hiromichi Shimizu Masakazu Nagahori Eiko Saito Ryuichi Okamoto Mamoru Watanabe Kazuo Ohtsuka

Published in: Alimentary pharmacology & therapeutics (2021)

Cytokine blocker treatment was less efficacious for small bowel inflammation than colonic inflammation. Higher serum concentrations were needed to achieve endoscopic remission of small bowel lesions.

Keyphrases

small bowel
oxidative stress
ulcerative colitis
angiotensin converting enzyme
ultrasound guided
combination therapy
bone marrow
cell therapy