Metabolic and dopaminergic correlates of intellectual enrichment in de-novo Parkinson's disease patients.

Stefano RaffaLuca SofiaNicola GirtlerMatteo PardiniDario ArnaldiBeatrice OrsoMaria I DoneganiFrancesca D'AmicoFrancesco LanfranchiGuido RoveraFederico MassaPietro MattioliGianmario SambucetiMatteo BaucknehtSilvia Morbelli

Published in: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... (2024)

CR proxies demonstrated to correlate directly with dopaminergic function and inversely with metabolism in cerebellar hemispheres in de-novo PD patients. The present multi-modal approach including both metabolic and dopaminergic correlates of CR allowed to identify possible compensation mechanisms, highlighting a potential role of the cerebellum that deserves further investigation.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
risk assessment
patient reported outcomes