Recent developments and applications of capillary and microchip electrophoresis in proteomics and peptidomics (mid 2018 - 2022).

This review gives a wide overview of recent advances and applications of CE and microchip CE methods in the fields of proteomics and peptidomics in the period from mid-2018 up to the end of 2022. The methodological topics covering sample preparation and concentration techniques, hyphenation of CE methods with MS, multidimensional separations by on-line or off-line coupled different CE and LC techniques are described and new developments in both bottom-up and top-down approaches in proteomics are presented. In addition, various applications of CE methods in proteomic and peptidomic studies are demonstrated. They include monitoring of protein posttranslational modifications and applications in biological and biochemical research, in clinical peptidomics and proteomics and in food analysis. This article is protected by copyright. All rights reserved.