Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.
Stefania IsolaLuca GammeriFabiana FurciSebastiano GangemiGiovanni PioggiaAlessandro AllegraPublished in: International journal of molecular sciences (2024)
Vitamin C is a water-soluble vitamin introduced through the diet with anti-inflammatory, immunoregulatory, and antioxidant activities. Today, this vitamin is integrated into the treatment of many inflammatory pathologies. However, there is increasing evidence of possible use in treating autoimmune and neoplastic diseases. We reviewed the literature to delve deeper into the rationale for using vitamin C in treating this type of pathology. There is much evidence in the literature regarding the beneficial effects of vitamin C supplementation for treating autoimmune diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) and neoplasms, particularly hematological neoplastic diseases. Vitamin C integration regulates the cytokines microenvironment, modulates immune response to autoantigens and cancer cells, and regulates oxidative stress. Moreover, integration therapy has an enhanced effect on chemotherapies, ionizing radiation, and target therapy used in treating hematological neoplasm. In the future, integrative therapy will have an increasingly important role in preventing pathologies and as an adjuvant to standard treatments.
Keyphrases
- systemic lupus erythematosus
- oxidative stress
- rheumatoid arthritis
- disease activity
- anti inflammatory
- systematic review
- water soluble
- multiple sclerosis
- stem cells
- early stage
- clinical trial
- dna damage
- physical activity
- ankylosing spondylitis
- interstitial lung disease
- low grade
- weight loss
- ischemia reperfusion injury
- current status
- induced apoptosis
- systemic sclerosis
- heat stress
- heat shock