STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury.

Amar AbdullahMoses ZhangTony FrugierSammy BedouiJuliet M TaylorPeter J Crack

Published in: Journal of neuroinflammation (2018)

Our data implicates a detrimental role for STING in mediating the TBI-induced neuroinflammatory response and autophagy dysfunction, potentially identifying a new therapeutic target for reducing cellular damage in TBI.

Keyphrases

traumatic brain injury
oxidative stress
diabetic rats
severe traumatic brain injury
high glucose
cell death
endoplasmic reticulum stress
electronic health record
signaling pathway
big data
drug induced
endothelial cells
artificial intelligence
deep learning