Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex.

calcium imaging in an unanesthetized mouse model of mild TBI to measure the effects of a focal injury of the motor cortex on the levels of cortical maps, area-wide connectivity, and neuronal populations in primary sensory cortex. By combining multiscale imaging, network analysis, and behavioral measures, our results illuminate the effects of focal brain injury on cortical function across spatial and temporal scales.