Pulsed field ablation prevents chronic atrial fibrotic changes and restrictive mechanics after catheter ablation for atrial fibrillation.
Yosuke NakataniSoumaya Sridi-ChenitiGhassen ChenitiF Daniel RamirezCyril GoujeauClementine AndréTakashi NakashimaCharles EggertChristopher SchneiderRaju ViswanathanPhilipp KrisaiTakamitsu TakagiTsukasa KamakuraKonstantinos VlachosNicolas DervalJosselin DuchateauThomas PambrunRemi ChauvelVivek Y ReddyMichel MontaudonFrançois LaurentFrederic SacherMélèze HociniMichel HaïssaguerrePierre JaïsHubert CochetPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2022)
Pulsed field ablation induces large acute LGE without microvascular damage or intramural haemorrhage. Most LGE lesions disappear in the chronic stage, suggesting a specific reparative process involving less chronic fibrosis. This process may contribute to a preserved tissue compliance and LA reservoir and booster pump functions.