Radiotheranostic Agent 64Cu-cyclam-RAFT-c(-RGDfK-)4 for Management of Peritoneal Metastasis in Ovarian Cancer.
Zhao-Hui JinAtsushi B TsujiMélissa DegardinAya SugyoSatoshi ObaraHidekatsu WakizakaKotaro NagatsuKuan HuMing-Rong ZhangPascal DumyDidier BoturynTatsuya HigashiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Collectively, these results demonstrate the all-in-one potential of 64Cu-RaftRGD for imaging guided radiotherapy of OCPM by targeting both tumoral neovessels and cancerous cells. On the basis of the ITD finding, we propose that pairing αVβ3- and hypoxia-targeted radiotherapies could improve therapeutic efficacy by overcoming the heterogeneity of ITD encountered with single-agent treatments.
Keyphrases
- acute myeloid leukemia
- induced apoptosis
- early stage
- cell cycle arrest
- high resolution
- aqueous solution
- single cell
- radiation therapy
- endothelial cells
- locally advanced
- radiation induced
- cancer therapy
- endoplasmic reticulum stress
- signaling pathway
- squamous cell carcinoma
- oxidative stress
- drug delivery
- cell proliferation