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Radiotheranostic Agent 64Cu-cyclam-RAFT-c(-RGDfK-)4 for Management of Peritoneal Metastasis in Ovarian Cancer.

Zhao-Hui JinAtsushi B TsujiMélissa DegardinAya SugyoSatoshi ObaraHidekatsu WakizakaKotaro NagatsuKuan HuMing-Rong ZhangPascal DumyDidier BoturynTatsuya Higashi
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Collectively, these results demonstrate the all-in-one potential of 64Cu-RaftRGD for imaging guided radiotherapy of OCPM by targeting both tumoral neovessels and cancerous cells. On the basis of the ITD finding, we propose that pairing αVβ3- and hypoxia-targeted radiotherapies could improve therapeutic efficacy by overcoming the heterogeneity of ITD encountered with single-agent treatments.
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