Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model.

Yuanqing LuNaweed S MohammadJungnam LeeAlek M AranyosKarina A SerbanMark L Brantly

Published in: PloS one (2024)

BBR exacerbated liver inflammation and fibrosis specifically in Pi*Z mice. This adverse effect may be associated with the activation of unfolded protein response and mTOR. This study implicates that BBR should be avoided by AATD patients.

Keyphrases

oxidative stress
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
cell proliferation
type diabetes
endoplasmic reticulum stress
emergency department
electronic health record