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Efficient bone regeneration of BMP9-stimulated human periodontal ligament stem cells (hPDLSCs) in decellularized bone matrix (DBM) constructs to model maxillofacial intrabony defect repair.

Yuxin ZhangWenping LuoLiwen ZhengJing HuLi NieHuan ZengXi TanYucan JiangYeming LiTianyu ZhaoZhuohui YangTong-Chuan HeHongmei Zhang
Published in: Stem cell research & therapy (2022)
The reported intrabony defect repair model can be used to identify optimized combinations of suitable seed cells and biological factors for bone defect repair and subsequent development of efficacious bone tissue engineering therapies.
Keyphrases
  • bone regeneration
  • tissue engineering
  • stem cells
  • bone mineral density
  • endothelial cells
  • induced apoptosis
  • cell cycle arrest
  • cell death
  • induced pluripotent stem cells
  • cell therapy
  • cell proliferation