Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis.
James DraperJodi AlexanderRohini M NairNicole ScullionRevu V L NarayanaKaren AughtonGeeta K VemugantiHelen KaliraiSarah E CouplandPublished in: Current eye research (2022)
Hypoxia pre-conditioning does not appear to drive a metastatic phenotype in UM; however, further understanding of how oxygen dynamics within the tumor microenvironment regulates HIF1 signaling is needed to determine whether inhibitors of HIF signaling represent a therapeutic option in metastatic UM.