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Using the Chick Embryo Model to Examine the Effects of Hypoxia Pre-conditioning of Uveal Melanoma Cells on Tumor Growth and Metastasis.

James DraperJodi AlexanderRohini M NairNicole ScullionRevu V L NarayanaKaren AughtonGeeta K VemugantiHelen KaliraiSarah E Coupland
Published in: Current eye research (2022)
Hypoxia pre-conditioning does not appear to drive a metastatic phenotype in UM; however, further understanding of how oxygen dynamics within the tumor microenvironment regulates HIF1 signaling is needed to determine whether inhibitors of HIF signaling represent a therapeutic option in metastatic UM.
Keyphrases
  • endothelial cells
  • squamous cell carcinoma
  • small cell lung cancer
  • pregnant women