One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [99mTc]Tc-DB4 and [111In]In-SG4 in Mice Treated with Entresto.

Panagiotis KanellopoulosAikaterini KaloudiMaritina RouchotaGeorge LoudosMarion de JongEric P KrenningBerthold A Nock Theodosia Maina

Published in: Pharmaceutics (2020)

This study has shown the efficacy of Entresto to notably improve the profile of [99mTc]Tc-DB4 and [111In]In-SG4 in mice, paving the way for clinical translation of this approach.

Keyphrases

high fat diet induced
cancer therapy
metabolic syndrome
skeletal muscle
adipose tissue
insulin resistance
newly diagnosed