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Osteopontin is elevated in patients with mitral annulus calcification independent from classic cardiovascular risk factors.

Michael SponderChristian ReuterMonika Fritzer-SzekeresBrigitte LitschauerThomas BinderJeanette Strametz-Juranek
Published in: BMC cardiovascular disorders (2016)
This is the first clinical trial which observed increased circulating OPN levels in MAC, suggesting a distinct role of OPN in the process of MAC. Considering the current knowledge about OPN it is more likely that OPN does not promote but counteracts valve calcification and therefore is elevated in course of a calcification processes.
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