Meeting Report: DMDG Peptide and Oligonucleotide ADME Workshop 2022.
Jesper Kammersgaard ChristensenInga BjørnsdottirAnders SonessonSteve HoodPublished in: Xenobiotica; the fate of foreign compounds in biological systems (2023)
Challenges within peptide and oligonucleotide ADME (absorption, distribution, metabolism and elimination) and scientific ideas on how to solve them were presented and discussed at the DMDG (Drug Metabolism and Discussion Group) Peptide and Oligonucleotide ADME Workshop 2022 (2 nd and 3 rd of October 2022). This meeting report summarises the presentations and discussions from this workshop.The following topics were covered:Overview of the drug modality landscapeMetabolism & modellingAnalytical challengesDrug-drug interactions reports from industry working groupsRegulatory interactions.