Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction.

Ofer PragerLyna KamintskyLuisa A Hasam-HendersonKarl SchoknechtVera WuntkeIsmini PapageorgiouJutta SwolinskyValeria MuoioGuy Bar-KleinUdi VazanaUwe HeinemannAlon FriedmanRichard Kovács

Published in: Epilepsia (2019)

Our study presents a direct observation of gradually developing neurovascular decoupling during recurrent seizures and suggests pericytic injury as an inducer of vascular dysfunction in epilepsy.

Keyphrases

blood brain barrier
oxidative stress
temporal lobe epilepsy
cerebral ischemia
diabetic rats
high glucose
drug induced
endothelial cells