Increased Adhesive Potential of Antiphospholipid Syndrome Neutrophils Mediated by β2 Integrin Mac-1.

Gautam SuleWilliam J KelleyKelsey GockmanSrilakshmi YalavarthiAndrew P VreedeAlison L BankaPaula L BockenstedtOmolola Eniola-AdefesoChristian Lood

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

APS neutrophils demonstrate increased adhesive potential, which is dependent upon the activated form of Mac-1. In patients, this could lower the threshold for neutrophil-endothelium interactions, NETosis, and possibly thrombotic events.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
nitric oxide
prognostic factors
human health
patient reported