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An ON-OFF Magneto-Optical Probe of Anisotropic Biofluid Crystals: A β -Hematin Case Study.

Danielle KaraRobert J DeisslerRose Al HeloKyle BlasinskyBrian T GrimbergRobert Brown
Published in: IEEE transactions on magnetics (2021)
We have designed, developed and evaluated an innovative portable magneto-optical detector (MOD) in which a light beam with variable polarization passes through a fluid sample immersed in a variable magnetic field. The light intensity is measured downstream along the forward scattering direction. The field is turned on and off through the in-and-out motion of nearby permanent magnets. As a result, for sufficiently magnetically and optically anisotropic samples, the optical absorption is sensitive to changes in the light polarization. Both detection and characterization applications are therefore available. For instance, both the degree of malaria infection can be measured and hemozoin crystalline properties can be studied. We present experimental results for synthetic hemozoin, and describe them in terms of the basic physics and chemistry underlying the correlations of the directions of the external magnetic field and the light beam polarization. We connect this work to a commercialized product for malaria detection and compare it to other magneto-optical instruments and methods. We conduct tests of absorption parameters, the electric polarizability tensor, and we discuss the connection to magnetic and electric dipole moments.
Keyphrases
  • high speed
  • high resolution
  • plasmodium falciparum
  • real time pcr
  • high intensity
  • mass spectrometry
  • magnetic resonance imaging
  • electron microscopy
  • patient reported outcomes
  • contrast enhanced