Life Course Adiposity and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study.
Linjing ZhangLu TangTao HuangDong-Sheng FanPublished in: Annals of neurology (2020)
Our findings provide novel evidence supporting a causal role of higher adiposity, taken as a whole, on lower risk of ALS. A deeper understanding of the energy metabolism of ALS is more likely to identify feasible nutritional interventions and even novel therapeutic targets that might improve the survival of ALS patients. Ann Neurol 2020;87:434-441.