Investigation of the reinforcing potential of samidorphan and naltrexone by fixed and progressive ratio intravenous self-administration testing in heroin-maintained rats.
Sharon L SmithReginald L DeanMark S TodtenkopfDavid J HealPublished in: Journal of psychopharmacology (Oxford, England) (2019)
Overall, the profiles of samidorphan and naltrexone, which has no abuse liability, were similar in this model.