Reversal of propofol-induced depression of the hypoxic ventilatory response by BK-channel blocker ENA-001: a randomized controlled trial.

Simone C JansenMaarten van LemmenErik OlofsenLaurence MossJoseph V PergolizziThomas MillerRobert D ColucciMonique van VelzenPhilip KremerAlbert DahanRutger van der SchrierMarieke Niesters

Published in: Anesthesiology (2024)

In this pilot study, we demonstrated that ENA-001 restored the hypoxic ventilatory response impaired by propofol. This finding is not only of clinical importance, but also provides mechanistic insights into the peripheral stimulation of breathing with ENA-001 overcoming central depression by propofol.

Keyphrases

depressive symptoms
sleep quality
high glucose
diabetic rats
oxidative stress
physical activity
drug induced
endothelial cells
stress induced
chemotherapy induced