Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission.
Naveed SattarShahrad TaheriDavid P AstlingJessica ChadwickMichael A HinterbergMichael V HolmesEmma V TrothPaul WelshHadeel ZaghloulOdette ChagouryMike LeanRoy TaylorSteve WilliamsPublished in: Diabetes care (2023)
Intentional weight loss in recent-onset type 2 diabetes rapidly induces changes in protein-based risk models consistent with widespread cardiometabolic improvements, including cardiorespiratory fitness. Protein changes with greater (>10 kg) weight loss also predicted lower cardiovascular risk, providing a positive outlook for relevant ongoing trials.
Keyphrases
- weight loss
- bariatric surgery
- roux en y gastric bypass
- type diabetes
- glycemic control
- gastric bypass
- healthcare
- protein protein
- public health
- amino acid
- mental health
- cardiovascular disease
- binding protein
- obese patients
- weight gain
- insulin resistance
- clinical trial
- metabolic syndrome
- rheumatoid arthritis
- small molecule
- ulcerative colitis
- human health
- systemic lupus erythematosus
- climate change
- double blind