RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex.

Debin XuJichun YuYuting YangYunyan DuHongcheng LuShouhua ZhangQian FengYi YuLiang HaoJun ShaoLeifeng Chen

Published in: Cell & bioscience (2023)

Overall, our study identified the mechanism underlying the regulation of PKM alternative splicing in ATC cells for the first time and provides evidence about the effect of RBX1 on cellular adaptation to metabolic stress.

Keyphrases

induced apoptosis
cell cycle arrest
high intensity
histone deacetylase
cell proliferation