NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype.
Inés Muela-ZarzuelaJuan Miguel Suarez-RiveroAndrea Gallardo-OrihuelaChun WangKumi IzawaMarta de Gregorio-ProcopioIsabelle CouillinBernhard RyffelJiro KitauraAlberto SanzThomas von ZglinickiGabriel MbalavieleMario D CorderoPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)
Our findings show that NLRP1 is a cGAS-dependent DNA damage sensor during senescence and a mediator of SASP release through GSDMD. This study advances the knowledge on the biology of the NLRP1 inflammasome and highlights this pathway as a potential pharmcological target to modulate senescence.