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A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.

Abhinav KumarWachirun TerakosolphanMireille HassounKalliopi-Kelli VanderaAstrid NovickyRichard HarveyPaul G RoyallElif Melis BicerJonny ErikssonKatarina EdwardsDirk ValkenborgInge NelissenDave HassallIan S MudwayBen Forbes
Published in: Pharmaceutical research (2017)
The SLF reported herein constitutes a biorelevant synthetic simulant which is suitable to study biopharmaceutical properties of inhalation medicines such as those being proposed for an inhaled biopharmaceutics classification system.
Keyphrases
  • respiratory tract
  • endothelial cells
  • cystic fibrosis
  • ionic liquid
  • induced pluripotent stem cells
  • drug release