Probody Therapeutic Design of 89Zr-CX-072 Promotes Accumulation in PD-L1-Expressing Tumors Compared to Normal Murine Lymphoid Tissue.

Danique GiesenLinda N BroerMarjolijn N Lub-de HoogeIrina PopovaBruce HowngMargaret T Nguyen Olga Vasiljeva Elisabeth G E de VriesMartin Pool

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

89Zr-CX-072 accumulates specifically in PD-L1-expressing tumors with limited uptake in murine peripheral lymphoid tissues. Our data may enable clinical evaluation of 89Zr-CX-072 whole-body distribution as a tool to support CX-072 drug development (NCT03013491).

Keyphrases

pet imaging
gene expression
electronic health record
computed tomography
machine learning
deep learning
artificial intelligence
pet ct