The PNPLA3 rs738409 C>G variant interacts with changes in body weight over time to aggravate liver steatosis, but reduces the risk of incident type 2 diabetes.

Ming-Feng XiaHuan-Dong LinLing-Yan ChenLi WuHui MaQian LiQiqige AletengYu HuWan-Yuan HeJian GaoHua BianXiao-Ying LiXin Gao

Published in: Diabetologia (2019)

The PNPLA3 GG genotype interacted with changes in body weight to aggravate liver steatosis but reduced the risk of incident type 2 diabetes in metabolically unhealthy participants.

Keyphrases

body weight
type diabetes
insulin resistance
cardiovascular disease
high fat diet
glycemic control
high fat diet induced
metabolic syndrome
skeletal muscle
binding protein
weight loss