Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau.

Guoyu LanXuhui ChenJie YangPan SunYue CaiAnqi LiYalin ZhuZhen LiuShaohua MaTengfei Guonull null

Published in: Annals of neurology (2024)

These findings suggest that higher Aβ burden may attenuate the p-Tau-associated microglial responses, and TREM2-related microglial reactivity may independently correlate with GAP-43-related presynaptic loss. This study highlights the two-edged role of microglial reactivity in AD and other neurodegenerative diseases. ANN NEUROL 2024.

Keyphrases

inflammatory response
lipopolysaccharide induced
lps induced
neuropathic pain
spinal cord injury
neural network