Roles of TRP Channels in Neurological Diseases.
Rui WangSheng TuJianmin ZhangAnwen ShaoPublished in: Oxidative medicine and cellular longevity (2020)
Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the cerebral vascular endothelium and smooth muscle. Members of this channel superfamily show a wide variety of mechanisms ranging from ligand binding to voltage, physical, and chemical stimuli, implying the promising therapeutic potential of TRP in neurological diseases. In this review, we focus on the physiological functions of TRP channels in the brain and the pathological roles in neurological disorders to explore future potential neuroprotective strategies.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- smooth muscle
- blood brain barrier
- brain injury
- resting state
- white matter
- induced apoptosis
- nitric oxide
- spinal cord
- functional connectivity
- human health
- mental health
- physical activity
- current status
- oxidative stress
- multiple sclerosis
- spinal cord injury
- signaling pathway
- climate change
- risk assessment
- genome wide identification
- endoplasmic reticulum stress
- binding protein