GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines.

Christopher N CultraraStephen D KozuchPoornema RamasundaramClaudia J HellerSunil ShahAdah E BeckDavid SabatinoJenny Zilberberg

Published in: BMC cancer (2018)

This work implicates GRP78 as a modulator of cell adhesion markers in MM and PCa. Our results may have clinical implications underscoring GRP78 as a potential therapeutic target to reduce the adhesive nature of metastatic tumors to the bone niche.

Keyphrases

cell adhesion
prostate cancer
endoplasmic reticulum stress
cell surface
multiple myeloma
squamous cell carcinoma
radical prostatectomy
small cell lung cancer
bone mineral density
bone loss
climate change