In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA.

Ayman Alzu'biEjlal Abu-El-RubBahaa Al-TradHiba AlzoubiHadeel Abu-El-RubDima AlbalsGamal T AbdelhadyNoor S BaderRawan AlmazariRaed M Al-Zoubi

Published in: Forensic toxicology (2024)

These results indicate that AB-FUBINACA can trigger oxidative stress and inflammation, and activate caspase-dependent apoptosis in the kidney, with these processes being possibly linked to disruption of mitochondrial complexes and could be an underlying mechanism of SCs-induced nephrotoxicity.

Keyphrases

oxidative stress
diabetic rats
induced apoptosis
dna damage
ischemia reperfusion injury
drug induced
cell death
high glucose
endoplasmic reticulum stress
heat shock
endothelial cells