Synthesis and crystal structure of topiramate azido-sulfate at 90 K and 298 K.
Prabhakar PriyankaBidarur K JayannaHaruvegowda Kiran Kumarnull VinayaThayamma R DivakaraHemmige S YathirajanChristopher GlidewellSean R ParkinPublished in: Acta crystallographica. Section E, Crystallographic communications (2022)
The low (90 K) and room (298 K) temperature crystal structures of topiramate azido-sulfate [systematic name 2,3:4,5-bis- O -(1-methyl-ethyl-idene)-β-d-fructo-pyran-ose azido-sulfate], C 12 H 19 N 3 O 8 S, an inter-mediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azido-sulfate ( I ) finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.