DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway.
Reinaldo S Dos SantosLaura MarroquiTeresa VelayosAne Olazagoitia-GarmendiaAmaia Jauregi-MiguelAinara Castellanos-RubioDecio L EizirikLuis CastañoIzortze SantinPublished in: Diabetologia (2018)
These observations support DEXI as the aetiological gene in the type 1 diabetes-associated 16p13 genomic region, and provide the first indication of a link between this candidate gene and the regulation of local antiviral immune responses in beta cells. Moreover, our results provide initial information on the function of DEXI.
Keyphrases
- type diabetes
- copy number
- immune response
- genome wide
- oxidative stress
- endothelial cells
- induced apoptosis
- genome wide identification
- cardiovascular disease
- glycemic control
- dendritic cells
- single cell
- insulin resistance
- cell proliferation
- healthcare
- dna methylation
- gene expression
- metabolic syndrome
- cell death
- skeletal muscle
- bone marrow
- endoplasmic reticulum stress
- weight loss