Modeling Extraordinary Response Through Targeting Secondary Alterations in Fusion-Associated Sarcoma.

Fabio VanoliEvan SongJosephine Kam Tai K Dermawan Eve FishinevichPatricia SungSoe S Min Ziyu Xie Henry de Traux de Wardin Sinchun Hwang Robert G Maki Cristina R Antonescu

Published in: JCO precision oncology (2024)

These results highlight that additional targeted DNA NGS in chemotherapy-resistant translocation-associated sarcomas may reveal actionable oncogenic drivers occurring as secondary genetic events during disease progression.

Keyphrases

cancer therapy
genome wide
circulating tumor
single molecule
high grade
locally advanced
transcription factor
squamous cell carcinoma
dna methylation
rectal cancer