Patterns of Immune Dysregulation in Bipolar Disorder.
Benney M R ArgueLucas G CastenShaylah McCoolAysheh AlrfoohJenny Gringer RichardsJohn A WemmieVincent A MagnottaAislinn J WilliamsJacob J MichaelsonJess G FiedorowiczSabrina M ScrogginsMarie E GainePublished in: medRxiv : the preprint server for health sciences (2024)
Our findings indicate a significant immune component to bipolar disorder pathophysiology and genetic overlap with inflammatory bowel disease. This comprehensive study supports existing literature, whilst also highlighting novel immune targets altered in individuals with bipolar disorder. Specifically, multiple lines of evidence indicate differences in the peripheral representation of monocytes and T cells are hallmarks of bipolar disorder.