ONO-1301 enhances post-transplantation survival of human induced pluripotent stem cell-derived cardiac tissue sheet by promoting angiogenesis.
Xiang QuJunjun LiLi LiuJingbo ZhangYing HuaKota SuzukiAkima HaradaMasako IshidaNoriko YoshidaDaisuke OkuzakiYoshiki SakaiYoshiki SawaShigeru MiyagawaPublished in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2023)
Slow-release ONO-1301 scaffold provided an efficient delivery method for thick hiPSC-CM tissue. ONO-1301 promotes angiogenesis between the host and graft and improves nutritional and oxygen supply, thereby enhancing the survival of transplanted cells, effectively improving ejection fraction, and therapeutic effects.
Keyphrases
- endothelial cells
- ejection fraction
- high glucose
- aortic stenosis
- induced apoptosis
- vascular endothelial growth factor
- free survival
- cell cycle arrest
- left ventricular
- wound healing
- diabetic rats
- induced pluripotent stem cells
- oxidative stress
- cell death
- endoplasmic reticulum stress
- signaling pathway
- transcatheter aortic valve replacement
- atrial fibrillation