A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer.

Kai Sun Yitian Xu Licheng Zhang Polly A Niravath Jorge G Darcourt Tejal Patel Bin S Teh Andrew M Farach Carlo Guerrero Sunil Mathur Mark A Sultenfuss Nakul Gupta Mary R Schwartz Susan L Haley Sindhu Nair Xiaoxian Li Thi Truc Anh Nguyen Joseph D Butner Joe E Ensor Jaime A Mejia Zhuyong Mei E Brian Butler Shu-Hsia Chen Eric H Bernicker Jenny C Chang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

The median OS increased by more than 2-fold in patients with clinical benefit. The therapy is a well-tolerated treatment in heavily pretreated patients with mTNBC. Early detection of increased effector and effector memory CD8 T cells and myeloids correlate with response and non-response, respectively.

Keyphrases

gene therapy
regulatory t cells
dendritic cells
squamous cell carcinoma
small cell lung cancer
type iii
radiation therapy
radiation induced
cell therapy
chemotherapy induced